Impact of Gestational Diabetes on Fetal Precursors and Lipoprotein Profile Book All Pages Purchase

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Impact of Gestational Diabetes on Fetal Precursors and Lipoprotein Profile is the best book to read presented by Universitat Rovira i Virgili on 2020 is very recommended for you if you search book quote . is the best book to read composed by Francisco Algaba Chueca, with page thickness 144 Pages. you can found book content bellow

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La diabetis mellitus gestacional (DMG) és una de les complicacions més comunes de l'embaràs i s'ha associat amb alteracions metabòliques i nutricionals maternes que pertorben les adaptacions metabòliques d'ell mateix. Aquests trastorns s'han associat amb patrons de creixement alterats i una major predisposició a desenvolupar malalties posteriors a la vida per la programació fetal. Les cèl·lules precursores fetals i el metabolisme dels lípids són components clau de la programació fetal que es poden veure directament afectats per la DMG. Aquest treball estudia l'impacte de la DMG en la funcionalitat de les cèl·lules precursores fetals trobades en la membrana amniòtica i en les característiques morfològiques i funcionals de les lipoproteïnes fetals, i també si aquestes alteracions potencials podrien programar el metabolisme fetal i contribuir directament a la major predisposició a malalties metabòliques i cardiovasculars durant el desenvolupament de la vida adulta. Portem a terme dos estudis observacionals cas-control amb DMG i embarassades amb tolerància normal a la glucosa. Vam demostrar que la DMG indueix canvis en les característiques biològiques de les cèl·lules mare mesenquimàtiques de la membrana amniòtica (AMSC), moltes de les quals estan relacionades amb paràmetres metabòlics fetals, el que suggereix que l'entorn de la DMG podria programar les cèl·lules mare i posteriorment afavorir la disfunció metabòlica més endavant en la vida. D'altra banda, trobem un contingut alterat de triglicèrids i lipoproteïnes de colesterol a la descendència de mares amb DMG dividida per categories de naixement. Concretament, els nounats amb pes adequat per a l'edat gestacional (AGA) mostren un perfil més similar als adults amb dislipidèmia i aterosclerosi que els nascuts de mares DMG. A més, trobem que les partícules de lipoproteïnes de baixa densitat (LDL) són biomarcadors potencials d'obesitat futura.


Impact of Gestational Diabetes on Fetal Precursors and Lipoprotein Profile



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