ISBN: 9789811335402
Reading Diabetes Mellitus subtitle full pages
The Book Diabetes Mellitus distribution by Springer in the year 2019-05-06 recommended to you if you find book quote Medical / Neuroscience, Medical / Endocrinology & Metabolism, Medical / Neurology, Science / Life Sciences / Neuroscience, Medical / General, . The Book authored by Yusaku Nakabeppu, Toshiharu Ninomiya, with count of page 248 Pages. you can see book review bellow
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
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