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Download Comparison of Three Algorithms for Initiation and Titration of Insulin Glargine in Insulin‐naive Patients with Type 2 Diabetes Mellitus (既往从未使用过胰岛素的2型糖尿病患者使用三种不同的启用与滴定甘精胰岛素剂量方案的比较). subtitle for free
Great expectations book Comparison of Three Algorithms for Initiation and Titration of Insulin Glargine in Insulin‐naive Patients with Type 2 Diabetes Mellitus (既往从未使用过胰岛素的2型糖尿病患者使用三种不同的启用与滴定甘精胰岛素剂量方案的比较). by John Wiley & Sons, Australia, Limited and Ruijin Hospital in date 2013 is very recommended with you if you search book about . Great expectations book composed by with page thickness Pages. you can look description at the bottom
Abstract Background Several titration algorithms can be used to adjust insulin dose and attain blood glucose targets. We compared clinical outcomes using three initiation and titration algorithms for insulin glargine in insulin‐naive patients with type 2 diabetes mellitus (T2DM); focusing on those receiving both metformin and sulfonylurea (SU) at baseline. Methods This was a pooled analysis of patient‐level data from prospective, randomized, controlled 24‐week trials. Patients received algorithm 1 (1 IU increase once daily, if fasting plasma glucose [FPG] > target), algorithm 2 (2 IU increase every 3 days, if FPG > target), or algorithm 3 (treat‐to‐target, generally 2–8 IU increase weekly based on 2‐day mean FPG levels). Glycemic control, insulin dose, and hypoglycemic events were compared between algorithms. Results Overall, 1380 patients were included. In patients receiving metformin and SU at baseline, there were no significant differences in glycemic control between algorithms. Weight‐adjusted dose was higher for algorithm 2 vs algorithms 1 and 3 (P = 0.0037 and P
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